Welcome to Fidelity Systems

Tools for Advanced DNA and Protein Technologies
TopoTaq DNA Polymerase. The most robust enzyme for PCR amplification

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Double helix Contact info:
Fidelity Systems
7961 Cessna Avenue
MD 20879-4117
301-527-0804 (tel)
301-527-8250 (fax)
Whole Genome Direct (WGD) Sequencing Technology
Methanopyrus kandleri
The Complete Genome
of the Hyperthermophile
Methanopyrus kandleri AV19
and Monophyly of
Archaeal Methanogens

Slesarev,A.I., Mezhevaya,K.V., Makarova,K.S.,
Polushin,N.N., Shcherbinina,O.V.,
Shakhova,V.V., Belova,G.I., Aravind,L.,
Natale,D.A., Rogozin,I.B., Tatusov,R.L.,
Wolf,Y.I., Stetter,K.O., Malykh,A.G.,
Koonin,E.V. and Kozyavkin,S.A. (2002)
Proc. Natl. Acad. Sci. U.S.A. 99, 4644-4649

EVOLUTION: Stripped Down to the Bare Essentials
Science 296, 431 (2002) Editors' Choice

A HAPPY MARRIAGE: advancing DNA polymerases with DNA topoisomerase
Trends in Biotech 20, 491 (2002) Journal Club
Major breakthrough in DNA sequencing technology
Direct Automated Sequencing of Bacterial Genomic DNA
At the Ninth International Genome Sequencing and Analysis Conference Dr. Bruce Roe from the University of Oklahoma presented his group's data on the successful automated sequencing of non-clonable and non-PCRable regions of Streptococcus pyogenes (1.92 Mb). The scientists used ThermoFidelase I and a new sequencing kit to sequence genomic DNA directly. This took less than a week from receiving new reagents to presenting the most stunning results to 1200 attendees of the conference. "It completely changed our finishing strategy" - said Dr. Roe.

Successful Sequencing of Non-sequenceable DNA
At the 10th Annual Cold Spring Harbor Meeting on Genome Mapping and Sequencing Dr. Elaine Mardis of Washington University presented data on using ThermoFidelase I in large scale sequencing projects. "This approach has proven successful in sequencing through stop regions of M13 or pUC subclones, and PCR products" - concluded Dr. Mardis.
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